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Precautions
Protonix accumulates in the tubules of parietal cells of the stomach and transforms into its active form which selectively interacts with the H+-K+-ATP-ase. Protonix inhibits this enzyme and prevents transfer of hydrogen ions from the parietal cells into the stomach cavity this way blocking the final stage of hydrochloric acid secretion. Protonix inhibits basal and stimulated (regardless type of a stimuli - acetylcholine, histamine, gastrin) secretion of hydrochloric acid. This medication is used to treat acute stage of duodenal or gastric ulcers, including those caused by treatment with anti-inflammatory non-steroid medications, gastroesophageal reflux disease (moderate and severe); Zollinger-Ellison syndrome, eradication of H. pylori in patients with a peptic ulcer to reduce the frequency of relapses.
Missed dose
Overdose
Store at room temperature between 15-30 C (59-86 F) away from light and moisture, kids and pets.
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Overdose
Protonix is able to decrease pH-dependent absorption of ketoconazole and other medications. Protonix also increases the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduction of ketoconazole effectiveness or increase of digoxin toxicity, respectively.
If you missed a dose take it the soonest. If it is almost time of your next dose just skip it and return to your regular dosage schedule. Never double dose this medication to compensate the missed dose.
Disclaimer
Store at room temperature between 15-30 C (59-86 F) away from light and moisture, kids and pets.
Hypersensitivity, hepatitis and cirrhosis combined with severe liver failure.
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Most common side effects may appear as diarrhea, nausea, vomiting, constipation, rash and headaches, dizziness, nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention. Allergic reaction is also possible: hives, swelling of face and tongue, rash.
Dosage and directions
Contraindications
Disclaimer
Hypersensitivity, hepatitis and cirrhosis combined with severe liver failure.
Drug interaction
If you missed a dose take it the soonest. If it is almost time of your next dose just skip it and return to your regular dosage schedule. Never double dose this medication to compensate the missed dose.
Take exactly as administered by your doctor. Usually for patients with stomach or duodenum ulcers, gastroesophageal reflux disease Protonix is recommended as 40 mg daily dose. Treatment continues mostly during four weeks. Combined treatment with antibiotics (amoxicillin and clarithromycin) directed eradicate H. pylori in patients with ulcers in stomach and duodenum requires Protonix 40 mg daily divided in two doses: take one tablet before breakfast and before supper, do not chew or crash it, eat it whole with a glass of water. In case you purchased Protonix oral granules take them mixed only with applesauce or apple juice to make swallowing easy. Do not use any other type of liquid or soft food for it. Do not crush, chew, or break a delayed-release tablet.
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